Backed by science

The Osato Research Institute (ORI) is a non-profit organization founded in 2004 and based in Gifu, Japan. ORI conducts and coordinates scientific programs and clinical studies that focus on our natural defense systems, healthy living, healthy aging, and Osato ‘fermented papaya preparation’ or FPP®, commercially known as Immun’Âge.

World-renowned scientists have been studying FPP® properties and as members of our scientific board, they have contributed to scientifically prove the effects of FPP® on the immune system, the antioxidative system, and the production of cellular energy.

Our members come from very different fields and many different countries. They communicate their research findings on FPP® at international academic conferences, at ORI scientific committee meetings, and in scientific journals.

Publications and references available on Medline (PubMed) and on ORI's website 

Yuki Hayashi President of Osato Research Institute

A letter from M. Yuki Hayashi

President of ORI

"I founded the Osato Research Institute (ORI) over twenty-five years ago with a goal in mind: the development of a dietary supplement that would help people live long and healthy lives.

Preventive healthcare, in my view, is the solution to reducing healthcare costs in Japan's super-aging society.

The crucial and decisive step in preventive healthcare involves educating the population about the benefits of a balanced diet and a healthy lifestyle, enabling them to ward off diseases and live in good health for a longer time.

I am also convinced that the daily consumption of fermented foods is an essential preventive action. The longevity of the Japanese, one of the longest in the world, is partly explained by a diet including fermented foods.

To achieve my goal, I had decided early on that ORI would invest in numerous scientific studies on FPP (Fermentation Papaya Preparation).

Today, we have scientific proof that FPP stimulates the antioxidant and immune systems, giving it both anti-aging properties and the ability to protect the body against various pathologies.

The journey has been long, but after twenty-five years and 53 clinical studies, we have been rewarded for our work with thousands of testimonials from people around the world who take Immun'Âge."

Benefits backed by 53 clinical studies

Immun’Âge is the only dietary supplement whose properties have been clinically demonstrated by more than 50 published studies by scientists and physicians worldwide, including the 2008 Nobel prize in Medicine.

Immuno-stimulating properties

→ Actions of FPP® on the cells of the immune system 
Dr. Lester Packer | ISBN 2-7046-1675-2

→ Nitric oxide synthesis and TNF-secretion in RAW 264.7 macrophages
G. Rimbach & co | PMID: 12659174

Anti-oxidative properties

→ Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype. A Randomized, Placebo-Controlled, Cross-Over Study.
F. Marotta & Co | PMID: 16804018

→ Advantages of Fermented Papaya on our health: Beneficial effects on oxidative stress and immunity: oxidative stress and chronic diseases.
Pr. Luc Montagnier | ISBN 2-7046-1675-2

On cellular energy production

→ Does Oral Supplementation of a Fermented Papaya Preparation Correct Respiratory Burst Function of Innate Immune Cells in Type 2 Diabetes Mellitus Patients.
Ryan Dickerson & co | PMID:25268638

Protection against oxidative stress in Alzheimer’s disease

Helps protect against oxidative stress-related damages caused by these diseases.

→ Oxidative Stress in Patients with Alzheimer’s Disease:
Effect of Extracts of Fermented Papaya Powder. 
M. BARBAGALLO & Co | Hindawi Publishing Corporation,Mediators of Inflammation, Article ID 624801

Protection against the electromagnetic field intolerance syndrome (EHS)

Diminution of oxidative stress and inflammatory phenomena, normalization of brain oxygenation

→ Osato International was granted in 2021 the
US patent N° US 10.993.980B2 for “Method for Treating Electrohypersensitivity with a Fermented Papaya Preparation”

Protection against cardiovascular diseases:

Helps maintain good cardiovascular health by protecting the body against the dysfunction of the inner lining of the blood vessels.

→ Cardioprotective effect of a biofermented nutraceutical on endothelial function in healthy middle-aged subjects.
F. MAROTTA & Co | PMID: 22533427

Respiratory tract protection

Helps fight infections by reducing the damaging effect of oxidative stress, thus boosting the natural defence of the respiratory mucous membrane. 

→ Is there a potential application of a fermented nutraceutical in acute respiratory illnesses?
F. MAROTTA & Co | PMID:22824755

Skin aging

Improvement of hydration, elasticity and uniformity of the skin; protection against skin aging

→ Testing a quality-controlled fermented nutraceutical on skin aging markers: an antioxidant controlled, double-blind study
N. ZERBINATI & Co | PMID:26998011

  • "FPP® has remarkable properties to combat oxidative stress and to stimulate the immune system."

    Prof. Luc Montagnier
    Immunologist
    2008 Nobel Prize of Medicine
    President of the World AIDS foundation

  • "We studied FPP® at the University of Southern California in our laboratories and demonstrated its antioxidant properties, but also a very important action of improving the immune system."

    Dr. Lester Packer
    University of Southern California Health Center, PhD

How long is papaya fermented to obtain Immun'Âge?

Our Fermented Papaya Preparation (FPP) is obtained after a 10-month fermentation process in Japan, which gives it its exceptional properties.

Are there any side effects from taking Immun’Âge?

After more than 25 years being sold worldwide, no side effects have ever been reported.

What is the best time to take Immun’Âge?

It is best to take Immun’Âge on an empty stomach. Taking it first thing in the morning or just before going to bed are the best times to not forget your daily dose!

Do not eat or drink anything within five minutes of taking Immun’Âge for a better absorption.

Proven benefits on your defense systems

Through the years, your body faces repetitive attacks caused by infections, your lifestyle (alcohol, tobacco, stress) and your environment (pollution, sun.)

These attacks end up overwhelming your defense systems, preventing the body from defending itself as well as it used to. They accelerate aging and cause diseases.

Immun’Âge helps your body by stimulating your defense systems

Healthy Aging Specific uses of Immun'Âge